Synaptic vesicle recycling at the calyx of Held
نویسندگان
چکیده
منابع مشابه
Quantitative analysis of vesicle recycling at the calyx of Held synapse.
Vesicle recycling is pivotal for maintaining reliable synaptic signaling, but its basic properties remain poorly understood. Here, we developed an approach to quantitatively analyze the kinetics of vesicle recycling with exquisite signal and temporal resolution at the calyx of Held synapse. The combination of this electrophysiological approach with electron microscopy revealed that ∼80% of vesi...
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How vesicle calcium sensors interact with calcium channels at synapses affects neurotransmitter release dynamics. In this issue of Neuron, Nakamura et al. (2015) propose that synaptic vesicles are tightly coupled around the perimeter of a voltage-gated calcium channel cluster.
متن کاملCalcium and Vesicle Recruitment at the Calyx of Held
When it comes to synaptic vesicles, synapses seem to know a thing or two about supply and demand. High-frequency stimulation increases exocytosis and results in an accelerated recruitment of additional vesicles within the nerve terminal, a process thought to rely on intracellular calcium. This week, Hosoi et al. took advantage of the accessibility of the presynaptic terminal at the calyx of Hel...
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Vesicle recycling was studied in the rat calyx of Held, a giant brainstem terminal involved in sound localization. Stimulation of brain slices containing the calyx-type synapse with a high extracellular potassium ion concentration in the presence of horseradish peroxidase resulted within several minutes in a reduction of the number of neurotransmitter vesicles and in the appearance of labeled e...
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The kinetics of different steps in synaptic-vesicle recycling, including exocytosis, internalization and repriming, have recently been estimated in various types of living cell.
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2011
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2010.212